HLA Disease Associations

We offer test kits for the following HLA associated diseases:

Coeliac Disease

Celiac disease is an autoimmune reaction triggered by gluten which is an ingredient of different cereals. If not diagnosed early this leads to chronic inflammation and destruction of the small intestine. Celiac disease is strongly associated with the DQA1*05:01- DQB1*02:01 and DQA1*03-DQB1*03:02 haplotype. Additionally, DR3, DR7 and DR11 alleles can be used as genetic markers.

Morbus Bechterew et al.

There is a strong association between HLA-B27 and a group of seronegative arthritic diseases like Morbus Bechterew or Morbus Reiter. Determination of HLA-B27 is an important tool in the diagnosis of these diseases. 


Treatment with antiretroviral drugs containing the active substance Abacavir (mainly in HIV therapy) is only allowed when the existence of HLA-B*5701 is excluded by molecular genetic methods, since otherwise it is possible that a hypersensitivity reaction against Abacavir may occur. 


Narcolepsy belongs to a groups of sleeping disorders (Dyssomnias) with symptoms like daytime somnolence, sleep paralysis and hallucinations. 98 % of the caucasian patients with narcolepsy have the DRB1*1501 – DQA1*0102 – DQB1*0602 haplotype. Therefore, HLA typing is helpful to confirm or exclude a diagnosis.

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