HLA Disease Associations

We offer test kits for the following HLA associated diseases:

Coeliac Disease

Celiac disease is an autoimmune reaction triggered by gluten which is an ingredient of different cereals. If not diagnosed early this leads to chronic inflammation and destruction of the small intestine. Celiac disease is strongly associated with the DQA1*05:01- DQB1*02:01 and DQA1*03-DQB1*03:02 haplotype. Additionally, DR3, DR7 and DR11 alleles can be used as genetic markers.

For celiac disease diagnostics we offer a HISTO TYPE SSP kit an a HISTO SPOT SSO kit (see Table below):

Morbus Bechterew et al.

There is a strong association between HLA-B27 and a group of seronegative arthritic diseases like Morbus Bechterew or Morbus Reiter. Determination of HLA-B27 is an important tool in the diagnosis of these diseases. 

For HLA-B27 diagnostic we offer serological tests, a classicla HISTO TYPE SSP kit and a realtime PCR kit (see Table below).

Abacavir

Treatment with antiretroviral drugs containing the active substance Abacavir (mainly in HIV therapy) is only allowed when the existence of HLA-B*5701 is excluded by molecular genetic methods, since otherwise it is possible that a hypersensitivity reaction against Abacavir may occur. 

Behcet’s disease is a chronic vasculitis characterized by recurrent oral ulcers, genital ulcers, ocular and skin involvement, and other multisystemic features. Despite a worldwide distribute Behcet’s disease clusters in an area from eastern Asia to the Mediterranean basin. HLA B*51 is a strong risk factor for the disease and can be used as a diagnostic tool.

We offer the HISTO TYPE B*57:01 / B*51 kit for determination of the associated alleles.

Narcolepsy

Narcolepsy belongs to a groups of sleeping disorders (Dyssomnias) with symptoms like daytime somnolence, sleep paralysis and hallucinations. 98 % of the caucasian patients with narcolepsy have the DRB1*15:01 – DQA1*01:02 – DQB1*06:02 haplotype. Therefore, HLA typing is helpful to confirm or exclude a diagnosis.

For the diagnosis of narcolepsy we offer A HISTO TYPE SSP kit (see Table below).

Please contact us!

Ordering

Phone: +49 (0) 6404 / 925-450
Fax: +49 (0) 6404 / 925-460

Customer Service

Phone: +49 (0) 6404 / 925-125
Fax: +49 (0) 6404 / 925-421

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