SSP kits for determination of KIR genotypes and their HLA ligands

Natural killer cells (NK) and some T lymphocytes have killer-cell immunoglobulin like receptors (KIRs) on their cell surface. The genetic region of the KIR receptors is characterized by a high variability. Defined HLA class I molecules could be identified as ligands for single KIR receptors.

In bone marrow transplantations, a certain disparity of KIR/HLA can influence the outcome of the transplantation. Furthermore, there are associations between particular KIR Genotypes and autoimmune diseases (e.g psoriasis) and a slower progression of an AIDS disease.

The KIR TYPE kit allows genotyping of 14 KIR Genen plus 2 Pseudogenes.
The Epitop-TYPE kit recognizes the alleles with the HLA specificities HLA-Cw Asn80,, HLA-Cw Lys80, HLA-B Bw4Threo, HLA-B Bw4Iso and HLA-A Bw4.


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Phone: +49 (0) 6404 / 925-450
Fax: +49 (0) 6404 / 925-460

Customer Service

Phone: +49 (0) 6404 / 925-125
Fax: +49 (0) 6404 / 925-421

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